Synthesis of a 2-Aryl-3-aroyl Indole Salt (OXi8007) Resembling Combretastatin A-4 with Application as a Vascular Disrupting Agent-Reference-Cited by-同舟云学术

Synthesis of a 2-Aryl-3-aroyl Indole Salt (OXi8007) Resembling Combretastatin A-4 with Application as a Vascular Disrupting Agent

Published:2013-09-09 Issue:9 Volume:76 Page:1668-1678
ISSN:0163-3864
Container-title:Journal of Natural Products
language:en
Short-container-title:J. Nat. Prod.

Author:

Hadimani Mallinath B.¹,MacDonough Matthew T.¹,Ghatak Anjan¹,Strecker Tracy E.¹,Lopez Ramona²,Sriram Madhavi¹,Nguyen Benson L.¹,Hall John J.¹,Kessler Raymond J.¹,Shirali Anupama R.¹,Liu Li²,Garner Charles M.¹,Pettit George R.³,Hamel Ernest⁴,Chaplin David J.⁵,Mason Ralph P.²,Trawick Mary Lynn¹,Pinney Kevin G.¹

Affiliation:

1. Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, Texas 76798-7348, United States

2. Department of Radiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9058, United States

3. Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287-1604, United States

4. Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick National Laboratory for Cancer Research, National Institutes of Health, Frederick, Maryland 21702, United States

5. Oxigene Inc., 701 Gateway Boulevard, Suite 210, South San Francisco, California 94080, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/np400374w

Reference53 articles.

1. Pinney, K. G.; Pettit, G. R.; Trawick, M. L.; Jelinek, C.; Chaplin, D. J.InAntitumor Agents from Natural Products,2nd ed.Cragg, G. M., Kingston, D. G. I., Newman, D. J., Eds.CRC Press, Taylor and Francis Group:Boca Raton, FL, 2011; pp27–64.

2. Hamel, E.InMicrotubule Targets in Cancer Therapy;Fojo, A. T., Ed.Humana Press:Totowa, NJ, 2008; pp1–20.

3. Isolation and structure of combretastatin

4. Antineoplastic Agents, 122. Constituents of Combretum caffrum

5. Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin

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