Synthesis of the Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitor, 3-[(1S,2S,3R)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977, Belzutifan); Efficient Replication of Established Approaches-Reference-Cited by-同舟云学术

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Synthesis of the Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitor, 3-[(1S,2S,3R)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977, Belzutifan); Efficient Replication of Established Approaches

Published:2023-09 Issue: Volume:128 Page:154691
ISSN:0040-4039
Container-title:Tetrahedron Letters
language:en
Short-container-title:Tetrahedron Letters

Author:

Hamal Khagendra B.,Pavlich Cyprian I.,Carlson Graham J.,Ching Wong Yu,Zhao Fangzhou,Zhang Qing,Klausmeyer Kevin K.,Pinney Kevin G.^ORCID

Funder

National Cancer Institute

Baylor University

National Institutes of Health

Office of the Vice President for Research, University of Minnesota

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference38 articles.

1. Nobel Prize in Physiology or Medicine 2019. https://www.nobelprize.org/prizes/medicine/2019/press-release/ (accessed 2022-11-02).

2. Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway;Kaelin;Mol. Cell,2008

3. HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression;Keith;Nat. Rev. Cancer,2012

4. Role and regulation of prolyl hydroxylase domain proteins;Fong;Cell Death Differ.,2008

5. Integrated molecular analysis of clear-cell renal cell carcinoma;Sato;Nat. Genet.,2013

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. FDA approved fluorine-containing drugs in 2023;Chinese Chemical Letters;2024-11

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