Allosteric Effects on Substrate Dissociation from Cytochrome P450 3A4 in Nanodiscs Observed by Ensemble and Single-Molecule Fluorescence Spectroscopy-Reference-Cited by-同舟云学术

Allosteric Effects on Substrate Dissociation from Cytochrome P450 3A4 in Nanodiscs Observed by Ensemble and Single-Molecule Fluorescence Spectroscopy

Published:2008-11-04 Issue:47 Volume:130 Page:15746-15747
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Nath Abhinav¹,Koo Peter K.¹,Rhoades Elizabeth¹,Atkins William M.¹

Affiliation:

1. Department of Medicinal Chemistry, University of Washington, Seattle, Washington, and Departments of Physics and Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja805772r

Reference20 articles.

1. IN VITRO AND IN VIVO DRUG INTERACTIONS INVOLVING HUMAN CYP3A

2. Current views on the fundamental mechanisms of cytochrome P450 allosterism

3. Midazolam Oxidation by Cytochrome P450 3A4 and Active-Site Mutants: an Evaluation of Multiple Binding Sites and of the Metabolic Pathway That Leads to Enzyme Inactivation

4. Resolution of Multiple Substrate Binding Sites in Cytochrome P450 3A4: The Stoichiometry of the Enzyme−Substrate Complexes Probed by FRET and Job's Titration

5. Kinetics and Thermodynamics of Ligand Binding by Cytochrome P450 3A4

Cited by 32 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. From cell membrane to endoplasmic reticulum: Tunable lipid membrane imaging by regulating the lipophilicity and internalization of carbon dots;Chemical Engineering Journal;2024-07

2. Selectivity of osilodrostat as an inhibitor of human steroidogenic cytochromes P450;The Journal of Steroid Biochemistry and Molecular Biology;2023-07

3. Theoretical Tools to Quantify Stochastic Fluctuations in Single-Molecule Catalysis by Enzymes and Nanoparticles;ACS Omega;2022-12-15

4. A comparative study of interfacial environments in lipid nanodiscs and vesicles;Biophysical Reports;2022-09

5. Investigation of the molecular and mechanistic basis for the regioselective metabolism of midazolam by cytochrome P450 3A4;Physical Chemistry Chemical Physics;2022