Discovery of CGS 27023A, a Non-Peptidic, Potent, and Orally Active Stromelysin Inhibitor That Blocks Cartilage Degradation in Rabbits-Reference-Cited by-同舟云学术

Discovery of CGS 27023A, a Non-Peptidic, Potent, and Orally Active Stromelysin Inhibitor That Blocks Cartilage Degradation in Rabbits

Published:1997-08-01 Issue:16 Volume:40 Page:2525-2532
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

MacPherson Lawrence J.¹,Bayburt Erol K.¹,Capparelli Michael P.¹,Carroll Brian J.¹,Goldstein Robert¹,Justice Michael R.¹,Zhu Lijuan¹,Hu Shou-ih¹,Melton Richard A.¹,Fryer Lynn¹,Goldberg Ron L.¹,Doughty John R.¹,Spirito Salvatore¹,Blancuzzi Vincent¹,Wilson Doug¹,O'Byrne Elizabeth M.¹,Ganu Vishwas¹,Parker David T.¹

Affiliation:

1. Research Department, Novartis Pharmaceuticals, 556 Morris Avenue, Summit, New Jersey 07901

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm960871c

Reference30 articles.

1. Recent advances in matrix metalloproteinase inhibitor research

2. Matrix Metalloproteinases: A Review

3. Proteoglycans of joint cartilage

4. Identification of a stromelysin cleavage site within the interglobular domain of human aggrecan. Evidence for proteolysis at this site in vivo in human articular cartilage.

Cited by 337 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Inhibition of the galactosyltransferase C1GALT1 reduces osteosarcoma cell proliferation by interfering with ERK signaling and cell cycle progression;Cancer Gene Therapy;2024-04-15

2. Chemosensitization of non-small cell lung cancer to sorafenib via non-hydroxamate s-triazinedione-based MMP-9/10 inhibitors;Bioorganic Chemistry;2024-03

3. Discovery of matrix metalloproteinase inhibitors as anti-skin photoaging agents;European Journal of Medicinal Chemistry;2024-03

4. Targeted Extracellular Protein Degradation by Dendronized DNA Chimeras;ACS Chemical Biology;2024-02-08

5. Design, synthesis and biological evaluation of arylsulfonamides as ADAMTS7 inhibitors;RSC Medicinal Chemistry;2024