Understanding the Origin of Unusual Stepwise Hydrogenation Kinetics in the Synthesis of the 3-(4-Fluorophenyl)morpholine Moiety of NK1 Receptor Antagonist Aprepitant-Reference-Cited by-同舟云学术

Understanding the Origin of Unusual Stepwise Hydrogenation Kinetics in the Synthesis of the 3-(4-Fluorophenyl)morpholine Moiety of NK1 Receptor Antagonist Aprepitant

Published:2005-12-07 Issue:1 Volume:10 Page:109-117
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Brands Karel M. J.¹,Krska Shane W.¹,Rosner Thorsten¹,Conrad Karen M.¹,Corley Edward G.¹,Kaba Mahmoud¹,Larsen Robert D.¹,Reamer Robert A.¹,Sun Yongkui¹,Tsay Fuh-Rong¹

Affiliation:

1. Departments of Process Research and Chemical Engineering Research and Development, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, U.S.A.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op0501895

Reference25 articles.

1. Preliminary findings on the role of neuropeptide suppression by topical agents in the management of rheumatoid arthritis

2. Involvement of neurokinin 1 and 2 receptors in viscerosensitive response to rectal distension in rats

3. Pathophysiology of platelets

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