High-Throughput Lipophilicity Measurement with Immobilized Artificial Membranes
Author:
Affiliation:
1. Novartis Institutes for BioMedical Research, WSJ-350.3.04, CH-4002 Basel, and GiMS mbH, Maulbeerstrasse 44, CH-4058 Basel
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm049377w
Reference23 articles.
1. Potential antitumor agents. II. Effects of modifications in the side chain of 1-formylisoquinoline thiosemicarbazone
2. Hydrophobicity and Central Nervous System Agents: On the Principle of Minimal Hydrophobicity in Drug Design
3. Drug-like properties and the causes of poor solubility and poor permeability
4. A New Substituent Constant, π, Derived from Partition Coefficients
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