Development of a New Generation of 4-Aminoquinoline Antimalarial Compounds Using Predictive Pharmacokinetic and Toxicology Models-Reference-Cited by-同舟云学术

Development of a New Generation of 4-Aminoquinoline Antimalarial Compounds Using Predictive Pharmacokinetic and Toxicology Models

Published:2010-04-05 Issue:9 Volume:53 Page:3685-3695
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ray Sunetra¹,Madrid Peter B.¹,Catz Paul¹,LeValley Susanna E.¹,Furniss Michael J.¹,Rausch Linda L.¹,Guy R. Kiplin²,DeRisi Joseph L.³⁴,Iyer Lalitha V.¹,Green Carol E.¹,Mirsalis Jon C.¹

Affiliation:

1. SRI International, 333 Ravenswood Avenue, Menlo Park, California 94025

2. Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, Memphis, Tennessee 38105

3. Department of Biochemistry and Biophysics, University of California—San Francisco, San Francisco, California

4. Howard Hughes Medical Institute, University of California—San Francisco, San Francisco, California

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm100057h

Reference25 articles.

1. Applications of high-throughput ADME in drug discovery

2. The Role of In Vitro ADME Assays in Antimalarial Drug Discovery and Development

3. Incorporation of an Intramolecular Hydrogen-Bonding Motif in the Side Chain of 4-Aminoquinolines Enhances Activity against Drug-Resistant P. falciparum

4. Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities

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