A New Class of Glucosidase Inhibitor:  Analogues of the Naturally Occurring Glucosidase Inhibitor Salacinol with Different Ring Heteroatom Substituents and Acyclic Chain Extension

Author:

Liu Hui1,Sim Lyann1,Rose David R.1,Pinto B. Mario1

Affiliation:

1. Department of Chemistry, Simon Fraser University, Burnaby, B.C., Canada V5A 1S6, and Department of Medical Biophysics, University of Toronto and Division of Molecular and Structural Biology, Ontario Cancer Institute, Toronto, ON, Canada M5G 2M9

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Reference19 articles.

1. For example:  Garcia-Olmeda, F.; Salcedo, G.; Sanchez-Monge, R.; Gomez, L.; Royo, L.; Carbonero, P.Oxford Surveys of Plant Molecular andCell Biology; Clarendon Press:  Oxford, 1987; Vol. 4, pp 275−334. Bompard-Gilles, C.; Rousseau, P.; Rouge, P.; Payan, F.Structure1996,4, 1441−1452. Vallee, F.; Kadziola, A.; Bourne, Y.; Juy, M.; Rodenburg, K. W.; Svensson, B.; Haser, R.Structure1998,6, 649−659. Strobl, S.; Maskos, K.; Wiegand, G.; Huber, R.; GomisRuth, F.X.; Glockshuber, R.Structure1998,6, 911−921.

2. A randomized double-blind trial of acarbose in type 2 diabetes shows improved glycemic control over 3 years (U.K. Prospective Diabetes Study 44)

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