Role of the thiosugar ring in the inhibitory activity of salacinol, a potent natural α-glucosidase inhibitor-Reference-Cited by-同舟云学术

Role of the thiosugar ring in the inhibitory activity of salacinol, a potent natural α-glucosidase inhibitor

Published:2024 Issue:7 Volume:14 Page:4471-4481
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Takashima Katsuki¹^ORCID,Nakamura Shinya¹,Nagayama Maiko¹,Marumoto Shinsuke²,Ishikawa Fumihiro¹^ORCID,Xie Weijia³^ORCID,Nakanishi Isao¹,Muraoka Osamu⁴,Morikawa Toshio⁴^ORCID,Tanabe Genzoh¹⁴^ORCID

Affiliation:

1. Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan

2. Joint Research Centre, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan

3. State Key Laboratory of Natural Medicines, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 2100009, P. R. China

4. Pharmaceutical Research and Technology Institute, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan

Abstract

In contrast to previous SAR studies of aza-compounds (23vs.24 and 25), the present study using analogues (26a–26c, 27c, and 28a–28c) of salacinol (1) revealed an essential role of the thiosugar ring in effectively inhibiting α-glucosidase.

Funder

Japan Society for the Promotion of Science London

Mochida Memorial Foundation for Medical and Pharmaceutical Research

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D3RA08485J

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3. Kotalanol, a Potent a-Glucosidase Inhibitor with Thiosugar Sulfonium Sulfate Structure, from Antidiabetic Ayurvedic Medicine Salacia reticulata.

4. Salaprionol and Ponkoranol with Thiosugar Sulfonium Sulfate Structure from Salacia prinoides and a-Glucosidase Inhibitory Activity of Ponkoranol and Kotalanol Desulfate

5. Effect of five-membered sugar mimics on mammalian glycogen-degrading enzymes and various glucosidases