Investigation of Cardiovascular Effects of Tetrahydro-β-carboline sstr3 antagonists

Author:

He Shuwen,Lai Zhong,Ye Zhixiong,Dobbelaar Peter H.,Shah Shrenik K.,Truong Quang,Du Wu,Guo Liangqin,Liu Jian,Jian Tianying,Qi Hongbo,Bakshi Raman K.,Hong Qingmei,Dellureficio James,Reibarkh Mikhail,Samuel Koppara,Reddy Vijay B.,Mitelman Stan,Tong Sharon X.,Chicchi Gary G.,Tsao Kwei-Lan,Trusca Dorina,Wu Margaret,Shao Qing,Trujillo Maria E.,Fernandez Guillermo1,Nelson Donald1,Bunting Patricia1,Kerr Janet1,Fitzgerald Patrick1,Morissette Pierre1,Volksdorf Sylvia1,Eiermann George J.,Li Cai,Zhang Bei,Howard Andrew D.,Zhou Yun-Ping,Nargund Ravi P.,Hagmann William K.

Affiliation:

1. Department of Safety Assessment, 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference25 articles.

1. Identification of Potent Non-Peptide Somatostatin Antagonists with sst3 Selectivity

2. Thurieau, C.; Poitout, L.; Galcera, M.; Moinet, C.; Gordon, T. D.; Morgan, B. A.; Bigg, D.; Pommier, J.β-Carboline Compounds. WO 1999/64420, December 16, 1999.

3. Troxler, T.; Hurth, K.; Hoyer, D.Beta-Carboline Derivatives and Its Pharmaceutical Use Against Depression and Anxiety. WO 2002/081471, April 2, 2002.

4. Decahydroisoquinoline derivatives as novel non-peptidic, potent and subtype-selective somatostatin sst3 receptor antagonists

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