Discovery of a Potent Dihydrooxadiazole Series of Non-ATP-Competitive MK2 (MAPKAPK2) Inhibitors
Author:
Affiliation:
1. Departments of †Medicinal Chemistry and ‡Inflammatory Disease, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/ml200238g
Reference27 articles.
1. p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases
2. p38 Pathway Kinases as Anti-inflammatory Drug Targets
3. The p38 mitogen-activated protein kinase (MAPK) pathway in rheumatoid arthritis
4. Efficacy and safety of pamapimod in patients with active rheumatoid arthritis receiving stable methotrexate therapy
5. Potential Adverse Effects Associated with Inhibition of p38α/β MAP Kinases
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