Optimal Aggregation of FcεRI with a Structurally Defined Trivalent Ligand Overrides Negative Regulation Driven by Phosphatases

Author:

Mahajan Avanika1,Barua Dipak23,Cutler Patrick1,Lidke Diane S.1,Espinoza Flor A.1,Pehlke Carolyn1,Grattan Rachel1,Kawakami Yuko4,Tung Chang-Shung2,Bradbury Andrew R. M.5,Hlavacek William S.23,Wilson Bridget S.1

Affiliation:

1. Department of Pathology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, United States

2. Theoretical Biology and Biophysics Group, Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, United States

3. Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, United States

4. Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, United States

5. Advanced Measurement Science Group, Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, United States

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

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