Enzymatic Reduction of Adamantanones to Chiral Adamantanol Intermediates for the Synthesis of 11-β-Hydroxysteroid Dehydrogenase Inhibitors-Reference-Cited by-同舟云学术

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Enzymatic Reduction of Adamantanones to Chiral Adamantanol Intermediates for the Synthesis of 11-β-Hydroxysteroid Dehydrogenase Inhibitors

Published:2014-08-05 Issue:8 Volume:18 Page:960-968
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Hanson Ronald L.¹,Goldberg Steven L.¹,Guo Zhiwei¹,Tully Thomas P.¹,Goswami Animesh¹,Ye Xiang-Yang²,Robl Jeffrey A.²,Patel Ramesh N.¹

Affiliation:

1. Early Phase Chemical Development, Research and Development, Bristol-Myers Squibb, One Squibb Drive, New Brunswick, New Jersey 08903, United States

2. Department of Chemistry, Research and Development, Bristol-Myers Squibb, P.O. Box 5400, Princeton, New Jersey 08543, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op5002098

Reference11 articles.

1. Blockade of Glucocorticoid Excess at the Tissue Level: Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 as a Therapy for Type 2 Diabetes

2. Inhibition of 11ß-hydroxysteroid dehydrogenase type 1 as a promising therapeutic target

3. Ye, X.Y.; Robl, J. A.Cyclic 11-Beta Hydroxysteroid Dehydrogenase Type 1 Inhibitors. U.S. Patent US 7,727,978, 2010.

4. Kula, M.R.InStereoselective Biocatalysis;Patel, R. N., Ed.Marcel Dekker:New York, 2000; pp839–866.

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2. Nicotinamide Adenine Dinucleotide (Phosphate) – NAD(P)/NAD(P)H ^1–7;Encyclopedia of Reagents for Organic Synthesis;2022-04-25

3. A Tailor-Made Self-Sufficient Whole-Cell Biocatalyst Enables Scalable Enantioselective Synthesis of (R)-3-Quinuclidinol in a High Space-Time Yield;Organic Process Research & Development;2019-07-12

4. Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3′-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor;Journal of Medicinal Chemistry;2017-06-05

5. The syntheses of [13 C6 ] and [phenyl-14 C(U)]BMS-816336, an inhibitor of 11β-hydroxysteroid dehydrogenase type 1, for type 2 diabetes;Journal of Labelled Compounds and Radiopharmaceuticals;2017-05-30

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