Design, Synthesis, and Structure−Activity Relationships of Novel 2-Substituted Pyrazinoylguanidine Epithelial Sodium Channel Blockers: Drugs for Cystic Fibrosis and Chronic Bronchitis-Reference-Cited by-同舟云学术

Design, Synthesis, and Structure−Activity Relationships of Novel 2-Substituted Pyrazinoylguanidine Epithelial Sodium Channel Blockers: Drugs for Cystic Fibrosis and Chronic Bronchitis

Published:2006-06-13 Issue:14 Volume:49 Page:4098-4115
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hirsh Andrew J.¹,Molino Bruce F.¹,Zhang Jianzhong¹,Astakhova Nadezhda¹,Geiss William B.¹,Sargent Bruce J.¹,Swenson Brian D.¹,Usyatinsky Alexander¹,Wyle Michael J.¹,Boucher Richard C.¹,Smith Rick T.¹,Zamurs Andra¹,Johnson M. Ross¹

Affiliation:

1. Parion Sciences Inc., 2525 Meridian Parkway, Suite 260, Durham, North Carolina 27713, Albany Molecular Research Inc., 21 Corporate Circle, Albany, New York 12212, and Cystic Fibrosis/Pulmonary Research and Treatment Center, School of Medicine, University of North Carolina at Chapel Hill, Thurston Bowles Building, Chapel Hill, North Carolina 27599

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm051134w

Reference45 articles.

1. Medicinal Chemistry of Neuronal Voltage-Gated Sodium Channel Blockers

2. Amiloride and its analogs as tools in the study of ion transport

3. Potassium-sparing effect of amiloride in a diuretic factorial study in man

4. Molecular insights into the physiology of the ‘thin film’ of airway surface liquid

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