N-Heteroaryl-2-phenyl-3-(benzyloxy)piperidines: A Novel Class of Potent Orally Active Human NK1 Antagonists-Reference-Cited by-同舟云学术

N-Heteroaryl-2-phenyl-3-(benzyloxy)piperidines: A Novel Class of Potent Orally Active Human NK1 Antagonists

Published:1996-01-01 Issue:15 Volume:39 Page:2907-2914
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ladduwahetty T.¹,Baker R.¹,Cascieri M. A.¹,Chambers M. S.¹,Haworth K.¹,Keown L. E.¹,MacIntyre D. E.¹,Metzger J. M.¹,Owen S.¹,Rycroft W.¹,Sadowski S.¹,Seward E. M.¹,Shepheard S. L.¹,Swain C. J.¹,Tattersall F. D.¹,Watt A. P.¹,Williamson D. W.¹,Hargreaves R. J.¹

Affiliation:

1. Neuroscience Research Centre, Merck Sharp and Dohme Research Laboratories, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, U.K., and Merck Research Laboratories, Rahway, New Jersey 07065

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9506534

Reference33 articles.

1. Responses of functionally identified neurones in the dorsal horn of the cat spinal cord to substance P, neurokinin A and physalaemin

2. Localisation and characterisation of substance P binding to human synovial tissue in rheumatoid arthritis.

3. The non-peptide neurokinin1 receptor antagonist, RP 67580, blocks neurogenic plasma extravasation in the dura mater of rats

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