Discovery of the First Non-cGMP Mimetic Small Molecule Activators of cGMP-Dependent Protein Kinase 1 α (PKG1α)-Reference-Cited by-同舟云学术

Discovery of the First Non-cGMP Mimetic Small Molecule Activators of cGMP-Dependent Protein Kinase 1 α (PKG1α)

Published:2021-07-16 Issue:8 Volume:12 Page:1275-1282
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Hanisak Jennifer¹,Soriano Aileen²,Adam Gregory C.³,Basso Andrea²,Bauman David⁴,Bell David²,Frank Emily²,O’Donnell Gregory³,Tawa Paul²,Verras Andreas⁵,Yu Yang¹,Zhang Lei⁶,Seganish W. Michael⁷^ORCID

Affiliation:

1. Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States

2. Mass Spectrometry and Biophysics, Computational and Structural Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States

3. Quantitative Biosciences, Merck & Co., Inc, West Point, Pennsylvania 19486, United States

4. Discovery Biology, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States

5. Computational and Structural Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States

6. Biologics Analytical Research and Development, Merck & Co., Inc., Kenilworth, New Jersey, 07033 United States

7. Discovery Chemistry, Merck & Co., Inc., South San Francisco, California 94080, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.1c00264

Reference38 articles.

1. Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association

2. Modulation of cGMP in Heart Failure: A New Therapeutic Paradigm

3. Function of cGMP-Dependent Protein Kinases as Revealed by Gene Deletion

4. Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms

5. Cyclic GMP-Dependent Protein Kinases and the Cardiovascular System

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1. Structural insights into selective small molecule activation of PKG1α;Communications Biology;2023-07-31

2. Mechanistic insights on novel small molecule allosteric activators of cGMP-dependent protein kinase PKG1α;Journal of Biological Chemistry;2022-09

3. Optimization and Mechanistic Investigations of Novel Allosteric Activators of PKG1α;Journal of Medicinal Chemistry;2022-07-25