The Discovery and Development of a Safe, Practical Synthesis of ABT-869-Reference-Cited by-同舟云学术

The Discovery and Development of a Safe, Practical Synthesis of ABT-869

Published:2009-10-28 Issue:6 Volume:13 Page:1419-1425
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Kruger Albert W.¹,Rozema Michael J.¹,Chu-Kung Alexander¹,Gandarilla Jorge¹,Haight Anthony R.¹,Kotecki Brian J.¹,Richter Steven M.¹,Schwartz Albert M.¹,Wang Zhe¹

Affiliation:

1. Abbott, Process Research and Development, 1401 Sheridan Road, North Chicago, Illinois 60064-6285, U.S.A.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op900208y

Reference27 articles.

1. Angiogenesis as a therapeutic target

2. Angiogenesis in cancer and other diseases

3. Discovery of N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-N‘-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-Aminoindazole-Based Orally Active Multitargeted Receptor Tyrosine Kinase Inhibitor

4. The first-generation route is similar to the route that emerged from Medicinal Chemistry.(2)

5. Testing found that the reaction mixture consumed glass at a rate of 0.54 cm/year. In the presence of NaHCO3the rate of glass erosion was 0.0 cm/year, but small amounts of etching still occurred by visual inspection.

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