Discovery of N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-N‘-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-Aminoindazole-Based Orally Active Multitargeted Receptor Tyrosine Kinase Inhibitor-Reference-Cited by-同舟云学术

Discovery of N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-N‘-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-Aminoindazole-Based Orally Active Multitargeted Receptor Tyrosine Kinase Inhibitor

Published:2007-03-08 Issue:7 Volume:50 Page:1584-1597
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Dai Yujia¹,Hartandi Kresna¹,Ji Zhiqin¹,Ahmed Asma A.¹,Albert Daniel H.¹,Bauch Joy L.¹,Bouska Jennifer J.¹,Bousquet Peter F.¹,Cunha George A.¹,Glaser Keith B.¹,Harris Christopher M.¹,Hickman Dean¹,Guo Jun¹,Li Junling¹,Marcotte Patrick A.¹,Marsh Kennan C.¹,Moskey Maria D.¹,Martin Ruth L.¹,Olson Amanda M.¹,Osterling Donald J.¹,Pease Lori J.¹,Soni Niru B.¹,Stewart Kent D.¹,Stoll Vincent S.¹,Tapang Paul¹,Reuter David R.¹,Davidsen Steven K.¹,Michaelides Michael R.¹

Affiliation:

1. Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064-6100, and Abbott Bioresearch Center, 100 Research Drive, Worcester, Massachusetts 01605-5314

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm061280h

Reference26 articles.

1. Angiogenesis in cancer and other diseases

2. Angiogenesis as a therapeutic target

3. Vascular-specific growth factors and blood vessel formation

4. Signal transduction by receptors with tyrosine kinase activity

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