Biaryl Ureas as Potent and Orally Efficacious Melanin Concentrating Hormone Receptor 1 Antagonists for the Treatment of Obesity-Reference-Cited by-同舟云学术

Biaryl Ureas as Potent and Orally Efficacious Melanin Concentrating Hormone Receptor 1 Antagonists for the Treatment of Obesity

Published:2005-06-24 Issue:15 Volume:48 Page:4746-4749
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Palani Anandan¹,Shapiro Sherry¹,McBriar Mark D.¹,Clader John W.¹,Greenlee William J.¹,Spar Brian¹,Kowalski Timothy J.¹,Farley Constance¹,Cook John¹,van Heek Margaret¹,Weig Blair¹,O'Neill Kim¹,Graziano Michael¹,Hawes Brian¹

Affiliation:

1. Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0503852

Reference16 articles.

1. Melanin-concentrating Hormone Receptor: An Orphan Receptor Fits the Key

2. Central nervous system control of food intake

3. Acute and chronic administration of melanin-concentrating hormone enhances food intake and body weight in Wistar and Sprague–Dawley rats

4. Chronic intracerebroventricular infusion of MCH causes obesity in mice

5. Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance

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