1. ADME Research Inc., 1-12-8 Senba-higashi, Minoh, Osaka 562-0035, Japan, School of Pharmacy, Shujitsu University, 1-6-1 Nishigawara, Okayama 703-8516, Japan, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina, Kyoto 607-8414, Japan, and Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan