Constraining Binding Hot Spots: NMR and Molecular Dynamics Simulations Provide a Structural Explanation for Enthalpy−Entropy Compensation in SH2−Ligand Binding-Reference-Cited by-同舟云学术

Constraining Binding Hot Spots: NMR and Molecular Dynamics Simulations Provide a Structural Explanation for Enthalpy−Entropy Compensation in SH2−Ligand Binding

Published:2010-07-26 Issue:32 Volume:132 Page:11058-11070
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Ward Joshua M.¹,Gorenstein Nina M.¹,Tian Jianhua¹,Martin Stephen F.¹,Post Carol Beth¹

Affiliation:

1. Department of Medicinal Chemistry, Markey Center for Structural Biology, and Purdue Cancer Center, Purdue University, West Lafayette, Indiana 47907, and Department of Chemistry and Biochemistry and The Institute of Cellular and Molecular Biology, The University of Texas, Austin, Texas 78712

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja910535j

Reference82 articles.

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4. Mann, A.InThe Practice of Medicinal Chemistry,2nd ed.Wermuth, C. G., Ed.Academic Press:London, UK, 2003; pp233−250.

5. DESIGN OF PEPTIDOMIMETICS

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