Inhibitors to the Src SH2 Domain: A Lesson in Structure–Thermodynamic Correlation in Drug Design
Author:
Publisher
Elsevier BV
Subject
Molecular Biology,Biochemistry,Biophysics
Reference40 articles.
1. Site-directed mutagenesis of the SH2- and SH3-coding domains of c-src produces varied phenotypes, including oncogenic activation of p60c-src.
2. Growth factor signaling by receptor tyrosine kinases
3. Rescue of osteoclast function by transgenic expression of kinase-deficient Src insrc−/− mutant mice
4. SH2 domains recognize specific phosphopeptide sequences
5. Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.
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