The Development of a Manufacturing Route for the GPIIb/IIIa Receptor Antagonist SB-214857-A. Part 2: Conversion of the Key Intermediate SB-235349 to SB-214857-A-Reference-Cited by-同舟云学术

The Development of a Manufacturing Route for the GPIIb/IIIa Receptor Antagonist SB-214857-A. Part 2: Conversion of the Key Intermediate SB-235349 to SB-214857-A

Published:2003-07-26 Issue:5 Volume:7 Page:663-675
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Atkins Richard J.¹,Banks Adam¹,Bellingham Richard K.¹,Breen Gary F.¹,Carey John S.¹,Etridge Stephen K.¹,Hayes Jerome F.¹,Hussain Nigel¹,Morgan David O.¹,Oxley Paul¹,Passey Stephen C.¹,Walsgrove Timothy C.¹,Wells Andrew S.¹

Affiliation:

1. Synthetic Chemistry, GlaxoSmithKline Pharmaceuticals, Old Powder Mills, Nr. Leigh, Tonbridge, Kent, TN11 9AN, UK

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op034023k

Reference23 articles.

1. Potent, Selective, Orally Active 3-Oxo-1,4-benzodiazepine GPIIb/IIIa Integrin Antagonists

2. Platelet Glycoprotein IIb-IIIa Antagonists as Prototypical Integrin Blockers: Novel Parenteral and Potential Oral Antithrombotic Agents

3. A New and Convergent Synthesis of (2S)-7-(4,4‘-Bipiperidinylcarbonyl)-2,3,4,5- tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetic Acid Using a Palladium-Catalysed Aminocarbonylation Reaction

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