Sites of Modification of Hemospan, a Poly(ethylene glycol)-Modified Human Hemoglobin for Use As an Oxygen Therapeutic-Reference-Cited by-同舟云学术

Sites of Modification of Hemospan, a Poly(ethylene glycol)-Modified Human Hemoglobin for Use As an Oxygen Therapeutic

Published:2008-10-07 Issue:11 Volume:19 Page:2163-2170
ISSN:1043-1802
Container-title:Bioconjugate Chemistry
language:en
Short-container-title:Bioconjugate Chem.

Author:

Vandegriff Kim D.¹,Malavalli Ashok¹,Mkrtchyan Gnel M.¹,Spann Stephanie N.¹,Baker Dale A.¹,Winslow Robert M.¹

Affiliation:

1. Sangart Inc., 6175 Lusk Boulevard, San Diego, California, 92121, and Department of Bioengineering, University of California, San Diego, La Jolla, California 92093

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

Link

https://pubs.acs.org/doi/pdf/10.1021/bc8002666

Reference21 articles.

1. Acharya, A. S., Manjula, B. N., and Smith, P.(1996)Hemoglobin crosslinkers. U.S. Patent 5,585,484.

2. MP4, a new nonvasoactive PEG-Hb conjugate

3. Site-Specific PEGylation of Hemoglobin at Cys-93(β): Correlation between the Colligative Properties of the PEGylated Protein and the Length of the Conjugated PEG Chain

4. Kinetics of NO and O2 binding to a maleimide poly(ethylene glycol)-conjugated human haemoglobin

5. Oxidation and haem loss kinetics of poly(ethylene glycol)-conjugated haemoglobin (MP4): dissociation between in vitro and in vivo oxidation rates

Cited by 20 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Scalable manufacturing platform for the production of PEGylated heme albumin;Biotechnology and Bioengineering;2022-09-26

2. Stability of Maleimide-PEG and Mono-Sulfone-PEG Conjugation to a Novel Engineered Cysteine in the Human Hemoglobin Alpha Subunit;Frontiers in Chemistry;2021-07-26

3. Poly(ethylene glycol) Surface-Conjugated Apohemoglobin as a Synthetic Heme Scavenger;Biomacromolecules;2020-03-18

4. Nanomedicines: A Potential Treatment for Blood Disorder Diseases;Frontiers in Bioengineering and Biotechnology;2019-11-28

5. Hemoglobin(βC93A)–Albumin Cluster: Mutation of Cysteine‐β93 to Alanine Allows Moderate Reduction of O 2 Affinity by Inositol Hexaphosphate;ChemBioChem;2019-05-17