Poly(ethylene glycol) Surface-Conjugated Apohemoglobin as a Synthetic Heme Scavenger
Author:
Affiliation:
1. William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio 43210, United States
Funder
National Institutes of Health
Publisher
American Chemical Society (ACS)
Subject
Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.biomac.0c00141
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1. Hemoglobinuria-related acute kidney injury is driven by intrarenal oxidative reactions triggering a heme toxicity response
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3. Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs
4. Free heme toxicity and its detoxification systems in human
5. When might transferrin, hemopexin or haptoglobin administration be of benefit following the transfusion of red blood cells?
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