1. Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10, Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan, Department of Genetics and Molecular Biology, Kyoto University, Kyoto 606-8507, Japan, and School of Dentistry, Showa University, Tokyo 142-8555, Japan