1. Department of Pharmaceutical Sciences, University of Bologna, via Belmeloro 6, Department of Internal Medicine and Gastroenterology, University of Bologna, via Massarenti 9, 40126 Bologna, Italy, and Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise “G. Caporale”, Campo Boario, 64100 Teramo, Italy