A Robust Process for an mGluR5 Negative Allosteric Modulator: Difluoromethylation and Sonogashira Coupling on Large Scale-Reference-Cited by-同舟云学术

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A Robust Process for an mGluR5 Negative Allosteric Modulator: Difluoromethylation and Sonogashira Coupling on Large Scale

Published:2012-11-07 Issue:11 Volume:16 Page:1854-1860
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Sperry Jeffrey B.¹²,Farr Roger M.¹²,Levent Mahmut¹²,Ghosh Mousumi¹²,Hoagland Steven M.¹²,Varsolona Richard J.¹²,Sutherland Karen¹²

Affiliation:

1. Department of Chemical and Pharmaceutical Development, Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965, United States

2. Chemical Engineering and Technology, Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op3002728

Reference27 articles.

1. Positive and negative allosteric modulation of metabotropic glutamate receptors: emerging therapeutic potential

2. hERG potassium channels and cardiac arrhythmia

3. Antibacterial activity of pyrrolopyridine-substituted oxazolidinones: synthesis and in vitro SAR of various C-5 acetamide replacements

4. Reaction Safety: A Critical Parameter in the Development of a Scaleable Synthesis of 2,3-Bis-chloromethylpyridine Hydrochloride

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