Hydroxamic Acids As a Novel Family of Serine Racemase Inhibitors: Mechanistic Analysis Reveals Different Modes of Interaction with the Pyridoxal-5′-phosphate Cofactor-Reference-Cited by-同舟云学术

Hydroxamic Acids As a Novel Family of Serine Racemase Inhibitors: Mechanistic Analysis Reveals Different Modes of Interaction with the Pyridoxal-5′-phosphate Cofactor

Published:2009-09-11 Issue:19 Volume:52 Page:6032-6041
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hoffman Hillary E.¹²,Jirásková Jana¹²,Cígler Petr¹,Šanda Miloslav¹,Schraml Jan³,Konvalinka Jan¹²

Affiliation:

1. Gilead Sciences and IOCB Research Center, Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i., Flemingovo n. 2, 166 10 Prague 6, Czech Republic

2. Department of Biochemistry, Faculty of Science, Charles University, Hlavova 8, Prague 2, Czech Republic

3. Institute of Chemical Process Fundamentals of the ASCR, v. v. i., Rozvojová 135, 165 02 Prague 6, Czech Republic

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm900775q

Reference43 articles.

1. D-Serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor

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3. Possible role of d-serine in the pathophysiology of Alzheimer's disease