Identification of Novel Binding Interactions in the Development of Potent, Selective 2-Naphthamidine Inhibitors of Urokinase. Synthesis, Structural Analysis, and SAR of N-Phenyl Amide 6-Substitution-Reference-Cited by-同舟云学术

Identification of Novel Binding Interactions in the Development of Potent, Selective 2-Naphthamidine Inhibitors of Urokinase. Synthesis, Structural Analysis, and SAR of N-Phenyl Amide 6-Substitution

Published:2003-12-12 Issue:2 Volume:47 Page:303-324
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wendt Michael D.¹,Rockway Todd W.¹,Geyer Andrew¹,McClellan William¹,Weitzberg Moshe¹,Zhao Xumiao¹,Mantei Robert¹,Nienaber Vicki L.¹,Stewart Kent¹,Klinghofer Vered¹,Giranda Vincent L.¹

Affiliation:

1. Cancer Research and Structural Biology, Global Pharmaceutical R & D, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064-6101

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0300072

Reference57 articles.

1. Augmented Urokinase Receptor Expression in Atheroma

2. Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation

3. Urokinase Plasminogen Activator Colocalizes with CD25+ Cells in Atherosclerotic Vessels

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