Axially Chiral 1,7-Naphthyridine-6-carboxamide Derivatives as Orally Active Tachykinin NK1 Receptor Antagonists: Synthesis, Antagonistic Activity, and Effects on Bladder Functions-Reference-Cited by-同舟云学术

Axially Chiral 1,7-Naphthyridine-6-carboxamide Derivatives as Orally Active Tachykinin NK1 Receptor Antagonists: Synthesis, Antagonistic Activity, and Effects on Bladder Functions

Published:1999-09-01 Issue:19 Volume:42 Page:3982-3993
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Natsugari Hideaki¹,Ikeura Yoshinori¹,Kamo Izumi¹,Ishimaru Takenori¹,Ishichi Yuji¹,Fujishima Akira¹,Tanaka Toshimasa¹,Kasahara Fumiko¹,Kawada Mitsuru¹,Doi Takayuki¹

Affiliation:

1. Pharmaceutical Research Division and Technology Development Department, Takeda Chemical Industries, Ltd., 2-17-85, Jusohonmachi, Yodogawa-ku, Osaka 532-8686, Japan, and Discovery Research Division, Takeda Chemical Industries, Ltd., 10 Wadai, Tsukuba-shi, Ibaraki 300-4293, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm990220r

Reference44 articles.

1. A Potent Nonpeptide Antagonist of the Substance P (NK 1 ) Receptor

2. Activity and Distribution of Binding Sites in Brain of a Nonpeptide Substance P (NK 1 ) Receptor Antagonist

3. Methoxytetrahydropyrans. A new series of selective and orally potent 5-lipoxygenase inhibitors

4. In vitro and in vivo biological activities of SR140333, a novel potent non-peptide tachykinin NK1 receptor antagonist

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