Scale-Up of an Enantioselective Overman Rearrangement for an Asymmetric Synthesis of a Glycine Transporter 1 Inhibitor-Reference-Cited by-同舟云学术

Scale-Up of an Enantioselective Overman Rearrangement for an Asymmetric Synthesis of a Glycine Transporter 1 Inhibitor

Published:2012-02-13 Issue:3 Volume:16 Page:484-494
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Chandramouli Sithamalli V.¹,Ayers Timothy A.¹,Wu Xiao-Dong¹,Tran Loc T.¹,Peers James H.¹,Disanto Rocco¹,Roberts Frederick¹,Kumar Narendra¹,Jiang Ying¹,Choy Nakyen¹,Pemberton Clive¹,Powers Matthew R.¹,Gardetto Anthony J.¹,D’Netto Geoffrey A.¹,Chen Xuemin¹,Gamboa Juan¹,Ngo Duc¹,Copeland Warren¹,Rudisill Duane E.¹,Bridge Andrew W.¹,Vanasse Benoit J.¹,Lythgoe David J.¹

Affiliation:

1. Molecular Innovative Therapeutics, Sanofi, U.S. Route 202-206, P.O. Box 6800, Bridgewater, New Jersey 08807, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op200378r

Reference30 articles.

1. Characterization of SSR103800, a selective inhibitor of the glycine transporter-1 in models predictive of therapeutic activity in schizophrenia☆

2. Glycine transporter 1 as a potential therapeutic target for schizophrenia-related symptoms: Evidence from genetically modified mouse models and pharmacological inhibition

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4. A study of the 3,3-sigmatropic rearrangement of chiral trichloroacetamidic esters

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