2-Alkynyl-8-aryl-9-methyladenines as Novel Adenosine Receptor Antagonists: Their Synthesis and Structure−Activity Relationships toward Hepatic Glucose Production Induced via Agonism of the A2B Receptor-Reference-Cited by-同舟云学术

2-Alkynyl-8-aryl-9-methyladenines as Novel Adenosine Receptor Antagonists: Their Synthesis and Structure−Activity Relationships toward Hepatic Glucose Production Induced via Agonism of the A2B Receptor

Published:2000-12-19 Issue:2 Volume:44 Page:170-179
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Harada Hitoshi¹,Asano Osamu¹,Hoshino Yorihisa¹,Yoshikawa Seiji¹,Matsukura Masayuki¹,Kabasawa Yasuhiro¹,Niijima Jun¹,Kotake Yoshihiko¹,Watanabe Nobuhisa¹,Kawata Tsutomu¹,Inoue Takashi¹,Horizoe Tatsuo¹,Yasuda Nobuyuki¹,Minami Hiroe¹,Nagata Kaya¹,Murakami Manabu¹,Nagaoka Junsaku¹,Kobayashi Seiichi¹,Tanaka Isao¹,Abe Shinya¹

Affiliation:

1. Tsukuba Research Laboratories, Eisai Company, Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm990499b

Reference53 articles.

1. The orphan receptor cDNA RDC7 encodes an A1 adenosine receptor.

2. Cloning and functional characterization of a human Al adenosine receptor

3. RDC8 codes for an adenosine A2 receptor with physiological constitutive activity

4. Molecular characterization of a human brain adenosine A2 receptor

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