Abstract
Metabolic syndrome is a multifactorial disease with high prevalence worldwide. It is related to cardiovascular disease, diabetes, and obesity. Approximately 80% of patients with metabolic syndrome have some degree of fatty liver disease. An adenosine derivative (IFC-305) has been shown to exert protective effects in models of liver damage as well as on elements involved in central metabolism; therefore, here, we evaluated the effect of IFC-305 in an experimental model of metabolic syndrome in rats induced by a high-fat diet and 10% sucrose in drinking water for 18 weeks. We also determined changes in fatty acid uptake in the Huh-7 cell line. In the experimental model, increases in body mass, serum triglycerides and proinflammatory cytokines were induced in rats, and the adenosine derivative significantly prevented these changes. Interestingly, IFC-305 prevented alterations in glucose and insulin tolerance, enabling the regulation of glucose levels in the same way as in the control group. Histologically, the alterations, including mitochondrial morphological changes, observed in response to the high-fat diet were prevented by administration of the adenosine derivative. This compound exerted protective effects against metabolic syndrome, likely due to its action in metabolic regulation, such as in the regulation of glucose blood levels and hepatocyte fatty acid uptake.
Funder
Consejo Nacional de Ciencia y Tecnología
Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México
Publisher
Public Library of Science (PLoS)
Reference50 articles.
1. The metabolic syndrome;RH Eckel;Lancet,2005
2. Clustering of metabolic factors and coronary heart disease;PW Wilson;Arch Intern Med,1999
3. World Obesity Atlas. No Title [Internet]. 2022. Available from: https://www.worldobesityday.org/policy-makers
4. Mexico and the USA: The world’s leaders in the obesity epidemic;JP Elder;Salud pública Méx,2013
5. Obesity;P González-Muniesa;Nat Rev Dis Primers,2017