Discovery of Ecopladib, an Indole Inhibitor of Cytosolic Phospholipase Α2α-Reference-Cited by-同舟云学术

Discovery of Ecopladib, an Indole Inhibitor of Cytosolic Phospholipase Α2α

Published:2007-02-17 Issue:6 Volume:50 Page:1380-1400
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lee Katherine L.¹,Foley Megan A.¹,Chen Lihren¹,Behnke Mark L.¹,Lovering Frank E.¹,Kirincich Steven J.¹,Wang Weiheng¹,Shim Jaechul¹,Tam Steve¹,Shen Marina W. H.¹,Khor SooPeang¹,Xu Xin¹,Goodwin Debra G.¹,Ramarao Manjunath K.¹,Nickerson-Nutter Cheryl¹,Donahue Frances¹,Ku M. Sherry¹,Clark James D.¹,McKew John C.¹

Affiliation:

1. Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm061131z

Reference61 articles.

1. Metabolism of platelet-activating factor by arachidonic acid-depleted rat polymorphonuclear leukocytes.

2. Protein kinase C activity appears to be required for the synthesis of platelet-activating factor and leukotriene B4 by human neutrophils.

3. Processive interfacial catalysis by mammalian 85-kilodalton phospholipase A2 enzymes on product-containing vesicles: Application to the determination of substrate preferences

4. Cytosolic phospholipase A2

Cited by 77 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Temporal dissociation of COX-2-dependent arachidonic acid and 2-arachidonoylglycerol metabolism in RAW264.7 macrophages;Journal of Lipid Research;2024-09

2. Thiourea/NCBSI/HCl System: Telescoping Alkyl Halide to Alkyl Sulfonyl Chloride by Recyclable N-Chloro-N-(phenylsulfonyl)benzene Sulfonamide (NCBSI);SynOpen;2024-07-16

3. Phospholipases A2;Metalloenzymes;2024

4. Identification of potential inhibitor(s) against phospholipase A2 using a network pharmacology-based approach;Phospholipases in Physiology and Pathology;2023

5. Discovery of substituted indole derivatives as allosteric inhibitors ofm⁶A‐RNAmethyltransferase,METTL3‐14 complex;Drug Development Research;2022-01-18