1. Department of Chemistry, Department of Psychiatry and Neurology, and Department of Life Science, Asahikawa Medical College, Asahikawa 078-8510, Japan, Department of Pathology, Case Western Reserve University, Wolstein Research Building, Room 5125, 2103 Cornell Road, Cleveland, Ohio 44106, College of Sciences, The University of Texas at San Antonio, 6900 North Loop 1604, West San Antonio, Texas 78249-0661, and Hokkaido Institute of Public Health, Kita 19, Nishi 12, Kita-ku, Sapporo 060-0819, Japan