Crystal Structures for HIV-1 Reverse Transcriptase in Complexes with Three Pyridinone Derivatives: A New Class of Non-Nucleoside Inhibitors Effective against a Broad Range of Drug-Resistant Strains-Reference-Cited by-同舟云学术

Crystal Structures for HIV-1 Reverse Transcriptase in Complexes with Three Pyridinone Derivatives: A New Class of Non-Nucleoside Inhibitors Effective against a Broad Range of Drug-Resistant Strains

Published:2005-11-02 Issue:24 Volume:48 Page:7582-7591
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Himmel Daniel M.¹,Das Kalyan¹,Clark, Arthur D.¹,Hughes Stephen H.¹,Benjahad Abdellah¹,Oumouch Said¹,Guillemont Jérôme¹,Coupa Sophie¹,Poncelet Alain¹,Csoka Imre¹,Meyer Christophe¹,Andries Koen¹,Nguyen Chi Hung¹,Grierson David S.¹,Arnold Eddy¹

Affiliation:

1. Center for Advanced Biotechnology and Medicine (CABM) and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854; HIV Drug Resistance Program, NCI-Frederick Cancer Research and Development Center, Building 539, Frederick, Maryland 21702; Laboratoire de Pharmacochimie, Section de Recherche, UMR 176 CNRS-Institut Curie, Batiment 110, Centre Universitaire, 91405 Orsay, France; Medicinal Chemistry Department, Johnson & Johnson Pharmaceutical Research and Development,...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0500323

Reference56 articles.

1. Crystal Structure at 3.5 Å Resolution of HIV-1 Reverse Transcriptase Complexed with an Inhibitor

2. Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA.

3. Locations of Anti-AIDS Drug Binding Sites and Resistance Mutations in the Three-dimensional Structure of HIV-1 Reverse Transcriptase

4. The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1.

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