Fenchylamine Sulfonamide Inhibitors of Amyloid β Peptide Production by the γ-Secretase Proteolytic Pathway: Potential Small-Molecule Therapeutic Agents for the Treatment of Alzheimer's Disease-Reference-Cited by-同舟云学术

Fenchylamine Sulfonamide Inhibitors of Amyloid β Peptide Production by the γ-Secretase Proteolytic Pathway: Potential Small-Molecule Therapeutic Agents for the Treatment of Alzheimer's Disease

Published:2000-05-23 Issue:12 Volume:43 Page:2297-2299
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Rishton Gilbert M.¹,Retz Daniel M.¹,Tempest Paul A.¹,Novotny James¹,Kahn Steve¹,Treanor James J. S.¹,Lile Jack D.¹,Citron Martin¹

Affiliation:

1. Amgen, One Amgen Center Drive, Thousand Oaks, California 91320-1789

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm990622z

Reference11 articles.

1. Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

2. Alzheimer's Disease--Genotypes, Phenotype, and Treatments

3. β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

4. Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease.

5. Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)

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