Potent, Brain-Penetrant, Hydroisoindoline-Based Human Neurokinin-1 Receptor Antagonists-Reference-Cited by-同舟云学术

Potent, Brain-Penetrant, Hydroisoindoline-Based Human Neurokinin-1 Receptor Antagonists

Published:2009-04-08 Issue:9 Volume:52 Page:3039-3046
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Jiang Jinlong¹,Bunda Jaime L.¹,Doss Geoge A.¹,Chicchi Gary G.¹,Kurtz Marc M.¹,Tsao Kwei-Lan C.¹,Tong Xinchun¹,Zheng Song¹,Upthagrove Alana¹,Samuel Koppara¹,Tschirret-Guth Richard¹,Kumar Sanjeev¹,Wheeldon Alan¹,Carlson Emma J.¹,Hargreaves Richard¹,Burns Donald¹,Hamill Terence¹,Ryan Christine¹,Krause Stephen M.¹,Eng WaiSi¹,DeVita Robert J.¹,Mills Sander G.¹

Affiliation:

1. Departments of Medicinal Chemistry, Immunology, and Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey 07065, Merck Sharp and Dohme-Neuroscience Research Center, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, U.K., and Imaging Research, Merck Research Laboratories, West Point, Pennsylvania 19486

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm8016514

Reference15 articles.

1. Structural Optimization Affording 2-(R)-(1-(R)-3,5-Bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor Antagonist

2. Efficacy and Safety of a Neurokinin-1 Receptor Antagonist in Postmenopausal Women With Overactive Bladder With Urge Urinary Incontinence

3. Effect of capsaicin on micturition and associated reflexes in chronic spinal rats

4. Distinct Mechanism for Antidepressant Activity by Blockade of Central Substance P Receptors

5. Evaluation of Potential Inductive Effects of Aprepitant on Cytochrome P450 3A4 and 2C9 Activity

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