Novel Second-Generation Di-2-Pyridylketone Thiosemicarbazones Show Synergism with Standard Chemotherapeutics and Demonstrate Potent Activity against Lung Cancer Xenografts after Oral and Intravenous Administration in Vivo-Reference-Cited by-同舟云学术

Novel Second-Generation Di-2-Pyridylketone Thiosemicarbazones Show Synergism with Standard Chemotherapeutics and Demonstrate Potent Activity against Lung Cancer Xenografts after Oral and Intravenous Administration in Vivo

Published:2012-08-03 Issue:16 Volume:55 Page:7230-7244
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lovejoy David B.¹,Sharp Danae M.¹,Seebacher Nicole¹,Obeidy Peyman¹,Prichard Thomas¹,Stefani Christian¹,Basha Maram T.²,Sharpe Philip C.²,Jansson Patric J.¹,Kalinowski Danuta S.¹,Bernhardt Paul V.²,Richardson Des R.¹

Affiliation:

1. Iron Metabolism and Chelation Program, Department of Pathology and Bosch Institute, University of Sydney, Sydney, New South Wales 2006, Australia

2. School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland 4072, Australia

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300768u

Reference58 articles.

1. Iron Chelators: Development of Novel Compounds with High and Selective Anti-Tumour Activity

2. Chelators at the Cancer Coalface: Desferrioxamine to Triapine and Beyond