Isosteric Replacement of Sulfur to Selenium in a Thiosemicarbazone: Promotion of Zn(II) Complex Dissociation and Transmetalation to Augment Anticancer Efficacy-Reference-Cited by-同舟云学术

Isosteric Replacement of Sulfur to Selenium in a Thiosemicarbazone: Promotion of Zn(II) Complex Dissociation and Transmetalation to Augment Anticancer Efficacy

Published:2024-07-05 Issue:14 Volume:67 Page:12155-12183
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kaya Busra¹,Gholam Azad Mahan¹,Suleymanoglu Mediha¹²,Harmer Jeffrey R.³^ORCID,Wijesinghe Tharushi P.¹,Richardson Vera¹,Zhao Xiao¹,Bernhardt Paul V.⁴^ORCID,Dharmasivam Mahendiran¹,Richardson Des R.¹⁵^ORCID

Affiliation:

1. Centre for Cancer Cell Biology and Drug Discovery, Griffith University, Nathan, Brisbane 4111, Australia

2. Department of Medical Biology, Istanbul Faculty of Medicine, Istanbul University, Fatih, Istanbul 34093, Turkey

3. Centre for Advanced Imaging, University of Queensland, Brisbane 4072, Australia

4. School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane 4072, Australia

5. Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan

Funder

National Breast Cancer Foundation

Thrasher Research Fund

National Health and Medical Research Council

Australian Research Council

Tour de Cure

Griffith University

T?rkiye Bilimsel ve Teknolojik Arastirma Kurumu

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00884

Reference131 articles.

1. Iron Chelators of the Di-2-pyridylketone Thiosemicarbazone and 2-Benzoylpyridine Thiosemicarbazone Series Inhibit HIV-1 Transcription: Identification of Novel Cellular Targets—Iron, Cyclin-Dependent Kinase (CDK) 2, and CDK9

2. Synthesis and evaluation of in vivo antioxidant, in vitro antibacterial, MRSA and antifungal activity of novel substituted isatin N- (2,3,4,6-tetra- O -acetyl-β -d- glucopyranosyl)thiosemicarbazones

3. Novel Second-Generation Di-2-Pyridylketone Thiosemicarbazones Show Synergism with Standard Chemotherapeutics and Demonstrate Potent Activity against Lung Cancer Xenografts after Oral and Intravenous Administration in Vivo

4. 2-Acetylpyridine Thiosemicarbazones are Potent Iron Chelators and Antiproliferative Agents: Redox Activity, Iron Complexation and Characterization of their Antitumor Activity

5. Dipyridyl Thiosemicarbazone Chelators with Potent and Selective Antitumor Activity Form Iron Complexes with Redox Activity

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