Analysis of Subpocket Selectivity and Identification of Potent Selective Inhibitors for Matriptase and Matriptase-2-Reference-Cited by-同舟云学术

Analysis of Subpocket Selectivity and Identification of Potent Selective Inhibitors for Matriptase and Matriptase-2

Published:2014-11-21 Issue:23 Volume:57 Page:10198-10204
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Duchêne Dominic¹,Colombo Eloïc¹,Désilets Antoine¹,Boudreault Pierre-Luc¹,Leduc Richard¹,Marsault Eric¹,Najmanovich Rafael¹

Affiliation:

1. Departments of Biochemistry and ‡Pharmacology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001 12e Avenue Nord, Sherbrooke, Quebec J1H 5N4, Canada

Funder

Canadian Institutes of Health Research

Fonds Québécois de la Recherche sur la Nature et les Technologies

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm5015633

Reference56 articles.

1. MEROPS: the database of proteolytic enzymes, their substrates and inhibitors

2. Serine peptidases: Classification, structure and function

3. Type II Transmembrane Serine Proteases

4. The Activation of Matriptase Requires Its Noncatalytic Domains, Serine Protease Domain, and Its Cognate Inhibitor

5. N-Glycosylation Is Required for Matriptase-2 Autoactivation and Ectodomain Shedding

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