The First Large-Scale Synthesis of MK-4305: A Dual Orexin Receptor Antagonist for the Treatment of Sleep Disorder-Reference-Cited by-同舟云学术

The First Large-Scale Synthesis of MK-4305: A Dual Orexin Receptor Antagonist for the Treatment of Sleep Disorder

Published:2011-03-04 Issue:2 Volume:15 Page:367-375
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Baxter Carl A.¹,Cleator Ed¹,Brands Karel M. J.²,Edwards John S.¹,Reamer Robert A.²,Sheen Faye J.¹,Stewart Gavin W.¹,Strotman Neil A.²,Wallace Debra J.¹

Affiliation:

1. Global Process Chemistry, Merck Sharp and Dohme Research Laboratories, Hertford Road, Hoddesdon, Hertfordshire EN11 9BU, U.K.

2. Global Process Chemistry, Merck Sharp and Dohme Research Laboratories, Rahway, New Jersey 07065, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op1002853

Reference9 articles.

1. Diagnosis and treatment of insomnia

2. Emerging drugs for insomnia: new frontiers for old and novel targets

3. Overview of Experimental and Conventional Pharmacological Approaches in the Treatment of Sleep and Wake Disorders

4. Narcolepsy in orexin Knockout Mice

5. Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia

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