Design and Synthesis of a Potent and Selective Triazolone-Based Peroxisome Proliferator-Activated Receptor α Agonist-Reference-Cited by-同舟云学术

Design and Synthesis of a Potent and Selective Triazolone-Based Peroxisome Proliferator-Activated Receptor α Agonist

Published:2003-10-18 Issue:24 Volume:46 Page:5121-5124
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Xu Yanping¹,Mayhugh Daniel¹,Saeed Ashraf¹,Wang Xiaodong¹,Thompson Richard C.¹,Dominianni Samuel J.¹,Kauffman Raymond F.¹,Singh Jaipal¹,Bean James S.¹,Bensch William R.¹,Barr Robert J.¹,Osborne John¹,Montrose-Rafizadeh Chahrzad¹,Zink Richard W.¹,Yumibe Nathan P.¹,Huang Naijia¹,Luffer-Atlas Debra¹,Rungta Deepa¹,Maise Dale E.¹,Mantlo Nathan B.¹

Affiliation:

1. Lilly Research Laboratories, A Division of Eli Lilly & Company, Lilly Corporate Center, Indianapolis, Indiana 46285, and Ligand Pharmaceuticals, 10275 Science Center Drive, San Diego, California 92121

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm034173l

Reference22 articles.

1. PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS: A Nuclear Receptor Signaling Pathway in Lipid Physiology

2. The PPARs: From Orphan Receptors to Drug Discovery

3. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

4. Increasing the Complexity of Coactivation in Nuclear Receptor Signaling

5. Peroxisome proliferator-activated receptors: from transcriptional control to clinical practice

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