1. Department of Pharmaceutical Sciences, School of Pharmacy, East China University of Science & Technology, Shanghai 200237, People’s Republic of China, Shanghai Institute of Materia Medica, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 201203, People’s Republic of China, and Department of Chemistry & Chemical Biology, University of New Mexico, Albuquerque, New Mexico 87131-0001