Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography-Reference-Cited by-同舟云学术

Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography

Published:2011-09-01 Issue:19 Volume:54 Page:6514-6530
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Patterson Stephen¹,Alphey Magnus S.¹,Jones Deuan C.¹,Shanks Emma J.¹,Street Ian P.²,Frearson Julie A.¹,Wyatt Paul G.¹,Gilbert Ian H.¹,Fairlamb Alan H.¹

Affiliation:

1. Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.

2. The Walter and Eliza Hall Institute of Medical Research, 1G Royal Pde, Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville VIC-3052, Australia

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm200312v

Reference57 articles.

1. Kinetoplastids: related protozoan pathogens, different diseases

2. Innovative lead discovery strategies for tropical diseases

3. METABOLISM AND FUNCTIONS OF TRYPANOTHIONE IN THE KINETOPLASTIDA

4. Trypanothione as a Target in the Design of Antitrypanosomal and Antileishmanial Agents

5. Dithiol Proteins as Guardians of the Intracellular Redox Milieu in Parasites: Old and New Drug Targets in Trypanosomes and Malaria-Causing Plasmodia

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