Fragment Merging, Growing, and Linking Identify New Trypanothione Reductase Inhibitors for Leishmaniasis-Reference-Cited by-同舟云学术

Fragment Merging, Growing, and Linking Identify New Trypanothione Reductase Inhibitors for Leishmaniasis

Published:2024-01-02 Issue:1 Volume:67 Page:402-419
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Exertier Cécile¹,Salerno Alessandra²^ORCID,Antonelli Lorenzo³,Fiorillo Annarita³,Ocello Riccardo²⁴,Seghetti Francesca²^ORCID,Caciolla Jessica²^ORCID,Uliassi Elisa²^ORCID,Masetti Matteo²^ORCID,Fiorentino Eleonora⁵,Orsini Stefania⁵,Di Muccio Trentina⁵,Ilari Andrea¹^ORCID,Bolognesi Maria Laura²^ORCID

Affiliation:

1. Institute of Molecular Biology and Pathology (IBPM) of the National Research Council of Italy (CNR), c/o Department of Biochemical Sciences, Sapienza University of Rome, Piazzale A. Moro 5, Roma 00185, Italy

2. Department of Pharmacy and Biotechnology, Alma Mater Studiorum─University of Bologna, Via Belmeloro 6, Bologna 40126, Italy

3. Department of Biochemical Sciences “A. Rossi Fanelli”, Sapienza University of Rome, Piazzale A. Moro 5, Roma 00185, Italy

4. Computational and Chemical Biology, Istituto Italiano di Tecnologia, via Morego 30, Genova 16163, Italy

5. Department of Infectious Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, Roma 00161, Italy

Funder

Ministero dell???Istruzione, dell???Universit?? e della Ricerca

Universit?? di Bologna

Collezione Nazionale di Composti Chimici e Centro di Screening

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01439

Reference45 articles.

1. Leishmaniasis

2. Leishmaniases in the European Union and Neighboring Countries

3. https://www.who.int/news-room/fact-sheets/detail/leishmaniasis#:~:text=Leishmaniasis%20is%20caused%20by%20protozoan,and%20lack%20of%20financial%20resources Accessed in August, 2023.

4. A road map for neglected tropical diseases 2021–2030

5. Challenges and recent progress in drug discovery for tropical diseases

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