Design and Synthesis of Antitumor Heck-Coupled Sclareol Analogues: Modulation of BH3 Family Members by SS-12 in Autophagy and Apoptotic Cell Death-Reference-Cited by-同舟云学术

Design and Synthesis of Antitumor Heck-Coupled Sclareol Analogues: Modulation of BH3 Family Members by SS-12 in Autophagy and Apoptotic Cell Death

Published:2015-04-09 Issue:8 Volume:58 Page:3432-3444
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Shakeel-u-Rehman ¹,Rah Bilal²³,Lone Shabir H.¹,Rasool Reyaz Ur²³,Farooq Saleem⁴,Nayak Debasis²³,Chikan Naveed Anjum⁵,Chakraborty Souneek³,Behl Akanksha³,Mondhe Dilip Manikaro²³,Goswami Anindya²³,Bhat Khursheed Ahmad¹

Affiliation:

1. Bioorganic Chemistry Division, Indian Institute of Integrative Medicine (CSIR), Srinagar, Jammu & Kashmir-190005, India

2. Academy of Scientific & Innovative Research, Indian Institute of Integrative Medicine, Jammu, Jammu & Kashmir-180001, India

3. Cancer Pharmacology Division, Indian Institute of Integrative Medicine (CSIR), Canal Road, Jammu Tawi, Jammu & Kashmir-180001, India

4. Bioorganic Chemistry Division, Indian Institute of Integrative Medicine (CSIR), Jammu, Jammu & Kashmir-180001, India

5. School of Bioscience and Technology, Division of Medical Biotechnology, VIT University, Vellore, Tamilnadu-632014, India

Funder

Council of Scientific and Industrial Research

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm501942m

Reference47 articles.

1. An abietane diterpene and two phenolics from Salvia forskahlei

2. Discovery and functional characterization of two diterpene synthases for sclareol biosynthesis in Salvia sclarea(L.) and their relevance for perfume manufacture

3. A short synthesis of ambrox® from sclareol

4. The effect of sclareol on growth and cell cycle progression of human leukemic cell lines

5. Labdane type diterpenes down-regulate the expression of c-myc protein, but not of bcl-2, in human leukemia T-cells undergoing apoptosis

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