Flavonoid Dimers as Bivalent Modulators for P-Glycoprotein-Based Multidrug Resistance: Synthetic Apigenin Homodimers Linked with Defined-Length Poly(ethylene glycol) Spacers Increase Drug Retention and Enhance Chemosensitivity in Resistant Cancer Cells-Reference-Cited by-同舟云学术

Flavonoid Dimers as Bivalent Modulators for P-Glycoprotein-Based Multidrug Resistance: Synthetic Apigenin Homodimers Linked with Defined-Length Poly(ethylene glycol) Spacers Increase Drug Retention and Enhance Chemosensitivity in Resistant Cancer Cells

Published:2006-10-17 Issue:23 Volume:49 Page:6742-6759
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chan Kin-Fai¹,Zhao Yunzhe¹,Burkett Brendan A.¹,Wong Iris L. K.¹,Chow Larry M. C.¹,Chan Tak Hang¹

Affiliation:

1. Department of Applied Biology and Chemical Technology and the Institute of Molecular Technology for Drug Discovery and Synthesis, The Hong Kong Polytechnic University, Hong Kong SAR, and State Key Laboratory in Chinese Medicine and Molecular Pharmacology, Shenzhen, China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm060593%2B

Reference85 articles.

1. P-glycoprotein—A mediator of multidrug resistance in tumour cells

2. Transmembrane Organization of Mouse P-glycoprotein Determined by Epitope Insertion and Immunofluorescence

3. Three-dimensional Structures of the Mammalian Multidrug Resistance P-glycoprotein Demonstrate Major Conformational Changes in the Transmembrane Domains upon Nucleotide Binding

Cited by 92 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synergistic effects of flavonoids and paclitaxel in cancer treatment: a systematic review;Cancer Cell International;2023-09-24

2. Identification of Binding Sites in the Nucleotide-Binding Domain of P-Glycoprotein for a Potent and Nontoxic Modulator, the Amine-Containing Monomeric Flavonoid FM04;Journal of Medicinal Chemistry;2023-04-25

3. The intracellular fate and transport mechanism of shape, size and rigidity varied nanocarriers for understanding their oral delivery efficiency;Biomaterials;2023-03

4. Apigenin improves cytotoxicity of antiretroviral drugs against HTLV-1 infected cells through the modulation of AhR signaling;NeuroImmune Pharmacology and Therapeutics;2023-02-17

5. Discovery of a Flavonoid FM04 as a Potent Inhibitor to Reverse P-Glycoprotein-Mediated Drug Resistance in Xenografts and Improve Oral Bioavailability of Paclitaxel;International Journal of Molecular Sciences;2022-12-04