Identification of Binding Sites in the Nucleotide-Binding Domain of P-Glycoprotein for a Potent and Nontoxic Modulator, the Amine-Containing Monomeric Flavonoid FM04

Author:

Liu Zhen1,Wong Iris L. K.1,Sang Jingcheng2,Liu Fufeng12,Yan Clare S. W.1,Kan Jason W. Y.1,Chan Tak Hang13,Chow Larry M. C.1ORCID

Affiliation:

1. Department of Applied Biology and Chemical Technology, State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hong Kong SAR, China

2. College of Biotechnology, Tianjin University of Science & Technology, Tianjin 300457, China

3. Department of Chemistry, McGill University, Montreal, Quebec H3A 2K6, Canada

Funder

Research Grants Council, University Grants Committee

Ministry of Human Resources and Social Security

National Natural Science Foundation of China

Hong Kong Polytechnic University

Society of Hong Kong Scholars

State Key Laboratory of the Chemical Biology and Drug Discovery

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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