Identification of Binding Sites in the Nucleotide-Binding Domain of P-Glycoprotein for a Potent and Nontoxic Modulator, the Amine-Containing Monomeric Flavonoid <b>FM04</b>-Reference-Cited by-同舟云学术

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Identification of Binding Sites in the Nucleotide-Binding Domain of P-Glycoprotein for a Potent and Nontoxic Modulator, the Amine-Containing Monomeric Flavonoid FM04

Published:2023-04-25 Issue:9 Volume:66 Page:6160-6183
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Liu Zhen¹,Wong Iris L. K.¹,Sang Jingcheng²,Liu Fufeng¹²,Yan Clare S. W.¹,Kan Jason W. Y.¹,Chan Tak Hang¹³,Chow Larry M. C.¹^ORCID

Affiliation:

1. Department of Applied Biology and Chemical Technology, State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Hong Kong SAR, China

2. College of Biotechnology, Tianjin University of Science & Technology, Tianjin 300457, China

3. Department of Chemistry, McGill University, Montreal, Quebec H3A 2K6, Canada

Funder

Research Grants Council, University Grants Committee

Ministry of Human Resources and Social Security

National Natural Science Foundation of China

Hong Kong Polytechnic University

Society of Hong Kong Scholars

State Key Laboratory of the Chemical Biology and Drug Discovery

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c02005

Reference60 articles.

1. The multi-factorial nature of clinical multidrug resistance in cancer

2. Mechanisms of Multidrug Resistance in Cancer Chemotherapy

3. Multidrug resistance in cancer: role of ATP–dependent transporters

4. Revisiting the role of ABC transporters in multidrug-resistant cancer

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